Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
Fluorescent nanodiamond-based spin-enhanced lateral flow immunoassay for detection of SARS-CoV-2 nucleocapsid protein and spike protein from different variantsArticle Published on 2022-10-162022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] anti-S IgG antibody Antigen antigens B.1.1.529 B.1.1.7 B.1.617.2 binding can be used comparable COVID-19 COVID-19 pandemic current Delta demonstrated Detection limit Diagnosis diagnostic Direct dropped ELISA finding Flow fluorescent Fluorescent nanodiamond incubated Infectious disease Laboratory Lateral lateral flow immunoassay limitations membrane mutations NC membrane nonspecific omicron platform Protein public health Quantitative reporter responsible S proteins SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SELFIA. Spike protein suggested the SARS-CoV-2 turnaround times variant variants viruses was performed wild-type Wuhan-1 [DOI] 10.1016/j.aca.2022.340389 PMC 바로가기
In vitro inhibition of SARS-CoV-2 Infection by dry algae powdersArticle Published on 2022-10-122022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral activity antiviral property Arthrospira candidate Chlorella COVID-19 CPE Culture DMEM DMSO experiment fucoidan highest in viral in vitro incubated Infection inhibited investigated Post-infection purified reduced Safe Sargassum SARS-CoV-2 SARS-COV-2 infection significantly solvent supernatant TCID therapeutic Treatment Vero Cell viral inoculum Viral RNA was increased was used [DOI] 10.1038/s41598-022-22148-6 PMC 바로가기
In vitro testing of salt coating of fabrics as a potential antiviral agent in reusable face masksArticle Published on 2022-10-112022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] added airway Antiviral cloth mask cloth masks collected conditions coronavirus disease COVID-19 cultures dependent on dilutions distribution Effectiveness eight epithelia epithelial evaluated Face mask Face masks H3N2 handling incubated mandatory Masks pandemic protocol quantified reduced relative remained risk Sodium chloride tested turn viral replication virus particle virus replication wearing face mask [DOI] 10.1038/s41598-022-21442-7 PMC 바로가기
Antiviral effect of multipurpose contact lens disinfecting solutions against coronavirusArticle Published on 2022-10-012022-11-15 Journal: Contact lens & anterior eye : the journal of the British Contact Lens [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Ammonium Antiviral antiviral activity Concentration conducted Contact Contact len Contact lens disinfection coronavirus coronavirus Detection limit evaluate Final FIVE hydrogen hydrogen peroxide incubated Iodine kill log mouse hepatitis virus negative control oxidative PBS phosphate buffer plaque forming unit quantified Quaternary ammonium. reduced reduction regimen SARS-CoV-2 significantly temperature Test treated Treatment virus virus [DOI] 10.1016/j.clae.2021.101513 PMC 바로가기
FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronavirusesArticle Published on 2022-09-012022-11-15 Journal: Journal of Lipid Research [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Cell click chemistry conserved coronavirus CoV CoV-229E Critical cysteine de novo enzyme epithelial cells examined expressed FASN fatty Fatty acid host cell Host cell entry human coronavirus in vitro incubated Infection inhibited inhibitor isoform Modification modify Multiple other coronavirus palmitate phylogenetically Prevent Protein reduction in reported residues S-acylation SARS-CoV-2 specificity spike coronavirus. Spike protein Spread the spike protein ZDHHC ZDHHC5 [DOI] 10.1016/j.jlr.2022.100256 PMC 바로가기
Proof-of-concept for speedy development of rapid and simple at-home method for potential diagnosis of early COVID-19 mutant infections using nanogold and aptamerArticle Published on 2022-09-012022-10-05 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] COVID19(2023년), SARS, 변종, 임상, 진단, 치료기술, [키워드] antibody Antigen Beta bind carried circulating clinical trial COVID COVID-19 COVID-19 virus Delta Diagnosis DNA early diagnosis Early-stage COVID-19 diagnosis Efficacy feasibility Flow Gamma Genome Gold nanoparticle incubated Infection Interaction Lateral lateral flow lateral flow assay less mRNA mutant mutants Mutation nitrocellulose Nitrocellulose membrane Oligonucleotide aptamer omicron overexpressed Patient peptide peptide synthesis positive probe produced Protein reported RNA RT-PCR S-protein single-stranded specificity Spike protein strain tested time-consuming variants Viral antigen viral infection viral particle viral surface was used [DOI] 10.1016/j.nano.2022.102590 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Boosts Neutralizing Activity Against Seasonal Human Coronaviruses중증 급성 호흡기 증후군 코로나바이러스 2 백신 접종은 계절성 인간 코로나바이러스에 대한 중화 활성을 향상시킵니다Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료법, [키워드] 229E activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against analyzed average BNT162b2 causative agent ChAdOx1 ChAdOx1 nCoV-19 circulating colds common cold Concentration coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccinations cross-neutralization cross-protection determined by Efficiency Endemic Gene Expression HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoVs Heterologous Huh-7 cells Human human coronavirus incubated individual inhibitory activity MERS MERS-CoV Middle East Middle East respiratory syndrome MOST neutralization neutralize Neutralizing activity NL63 nucleocapsid expression OC43 Preexisting immunity pseudoparticle pseudovirion pseudovirions reporter reporter gene respiratory SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 vaccination seasonal seasonal coronavirus seasonal coronaviruses seasonal coronaviruses. sera severe acute respiratory syndrome Coronavirus significantly increased Spike proteins these viruses vaccination Viral RNA virus [DOI] 10.1093/cid/ciac057 PMC 바로가기 [Article Type] Article
Sars-Cov-2 Spike Protein-Induced Damage of hiPSC-Derived CardiomyocytesSars-Cov-2 스파이크 단백질에 의한 hiPSC 유래 심근세포 손상Article Published on 2022-07-012022-09-12 Journal: Advanced Biology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 alteration Ang II angiotensin-converting enzyme 2 Cardiomyocytes chromatin cleavage complex connexin Culture damage downregulated Effect endocytic expression fluctuation functional hiPSC host cells incubated investigated margination molecular pluripotent stem cell Protein Proteins receptor SARS-CoV-2 spike Spike protein spike protein. Spike proteins Structure subunit the spike protein undergo virus while [DOI] 10.1002/adbi.202101327 PMC 바로가기 [Article Type] Article
Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses외피 RNA 바이러스에 대한 피리도벤조티아졸론 유도체 HeE1-17Y의 바이러스 살균 활성Article Published on 2022-05-272022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] active against activity alteration Analysis antivirals broad-spectrum antivirals Compound derivative enveloped viruses flavivirus incubated Infection inhibitor Interaction mechanism Microscopy mode non-enveloped viruses Particle reduced Replication reporter reporter replicon particles RNA SARS-CoV-2 shown these compound these compounds variety viral infectivity viral membrane Viral particles virucidal virucidal effect. virus viruses West Nile Virus [DOI] 10.3390/v14061157 PMC 바로가기 [Article Type] Article